Xanthine derivatives, including caffeine, prevent adenosine, hexobendine and regadenoson from working. Products are not equivalent on a weight basis and cannot be interchanged without adjusting the dose. Xanthine derivative Breastfeeding: Xanthines appear in breast milk. Tell your doctor or pharmacist if you are taking or planning to take any over­ the-counter or prescription medications or dietary supplements while taking xanthine bronchodilators. Clinical significance of xanthine derivatives. Mechanism of Action. Note that dyphylline is not converted to theophylline; thus, theophylline blood levels cannot be used to monitor its use. No. Keywords:Methylxanthines, xanthine derivatives, adenosine, adenosine receptors, subtype-selectivity, risk/benefit ratio, theophylline, cardiorespiratory disorders, caffeine, electrophysiological Abstract: Methylxanthines, such as theophylline, have been used to treat cardiorespiratory disorders, whereas caffeine is the most widely consumed psychoactive agent in various soft drinks. This review focuses on the molecular mechanisms involved in the actions of xanthine derivatives with special reference to their adenosine receptor antagonistic properties. Alkaloid-containing plants have been used by humans since ancient times for therapeutic and recreational purposes. These drugs may improve contraction of the diaphragm (the major breathing muscle) in patients with chronic obstructive airway disease. 2011;18(24):3695-706. doi: 10.2174/092986711796642391. for (var i=0;i xanthine derivatives uses reduce airway constriction & restore normal airflow is not substitute... 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